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Asymmetric Acral Spared Phenomenon Related to Systemic Anticancer Therapies
Author(s) -
Robert Baran,
Caroline Robert,
V. Sibaud
Publication year - 2018
Publication title -
skin appendage disorders
Language(s) - Uncategorized
Resource type - Journals
SCImago Journal Rank - 0.773
H-Index - 13
eISSN - 2296-9195
pISSN - 2296-9160
DOI - 10.1159/000486021
Subject(s) - medicine , phenomenon , philosophy , epistemology
We have observed three patients on anticancer therapies presenting with asymmetric acral spared phenomenon and found six identical cases in the literature. All of them had common features, an alteration of the peripheral nerves affecting a limb unilaterally that was spared by a hand-foot syndrome or hand-foot skin reaction. A drug-induced neurotropic effect sounds logical for developing such alterations with specific chemotherapeutic agents (taxanes, cap-ecitabine), while we have not found good explanations concerning the multikinase inhibitor sorafenib nor the topo isomerase inhibitor adriamycin. Nevertheless, we know that clinical manifestations of many inflammatory diseases need intact neural components.

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