Open AccessLong-Term Follow-Up of 4 Patients with Conjunctival Amyloidosis
Author(s) -
Alisa J. Prager,
Larissa A. Habib,
Talita Gambogi,
Klaus J. Busam,
Brian P. Marr
Publication year - 2018
Publication title -
ocular oncology and pathology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.444
H-Index - 10
eISSN - 2296-4681
pISSN - 2296-4657
DOI - 10.1159/000485918
Subject(s) - medicine , amyloidosis , biopsy , pathology , amyloid (mycology) , serum protein electrophoresis , conjunctiva , immunoglobulin light chain , antibody , monoclonal , monoclonal antibody , immunology
Conjunctival amyloidosis is a rare cause of ocular inflammation, mass, and hemorrhage that can be difficult to diagnose and treat. In this case series, we describe 4 patients with a histopathological diagnosis of conjunctival amyloidosis treated at a single institution. All patients underwent surgical excision and biopsy. On histopathological examination, 3 patients had local deposition of either kappa or lambda monoclonal immunoglobulin light chains, favoring localized amyloid light-chain amyloidosis. Systemic workup to exclude rheumatologic disorders (e.g., anti-neutrophil cytoplasmic antibody and rheumatoid factors) and hematological disorders (e.g., imaging, biopsies, and serum protein electrophoresis/urine protein electrophoresis) was negative except for a positive abdominal fat biopsy in 1 patient. Patients were followed for an average of 6.1 years (range 4 months to 15 years) with stable ocular disease.