Open AccessThe Protective Effects of Κ-Opioid Receptor Stimulation in Hypoxic Pulmonary Hypertension Involve Inhibition of Autophagy Through the AMPK-MTOR Pathway
Author(s) -
Yunyun Zhou,
Yuanbo Wang,
Xu Wang,
Xin Tian,
Shumiao Zhang,
Fan Yang,
Hongwei Guo,
Rong Fan,
Na Feng,
Min Jia,
Xiaoming Gu,
Yuemin Wang,
Juan Li,
Jianming Pei
Publication year - 2017
Publication title -
cellular physiology and biochemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.486
H-Index - 87
eISSN - 1421-9778
pISSN - 1015-8987
DOI - 10.1159/000485886
Subject(s) - autophagy , pi3k/akt/mtor pathway , ampk , opioid receptor , apoptosis , pharmacology , viability assay , hypoxia (environmental) , western blot , receptor , cell growth , chemistry , agonist , biology , phosphorylation , protein kinase a , biochemistry , organic chemistry , oxygen , gene
In a previous study, we showed that κ-opioid receptor stimulation with the selective agonist U50,488H ameliorated hypoxic pulmonary hypertension (HPH). However, the roles that pulmonary arterial smooth muscle cell (PASMC) proliferation, apoptosis, and autophagy play in κ-opioid receptor-mediated protection against HPH are still unknown. The goal of the present study was to investigate the role of autophagy in U50,488H-induced HPH protection and the underlying mechanisms.