Open AccessTroxerutin Protects Against Myocardial Ischemia/Reperfusion Injury Via Pi3k/Akt Pathway in Rats
Author(s) -
Liliang Shu,
Wanzhe Zhang,
Chen Huang,
Guofu Huang,
Gang Su
Publication year - 2017
Publication title -
cellular physiology and biochemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.486
H-Index - 87
eISSN - 1421-9778
pISSN - 1015-8987
DOI - 10.1159/000485884
Subject(s) - preload , medicine , myocardial infarction , lactate dehydrogenase , creatine kinase , ventricular pressure , protein kinase b , cardiology , pi3k/akt/mtor pathway , reperfusion injury , hemodynamics , ischemia , creatine , apoptosis , pharmacology , chemistry , enzyme , biochemistry
Troxerutin, also known as vitamin P4, has been commonly used in the treatment of chronic venous insufficiency (CVI) disease. However, its effect on in vivo myocardial ischemia/reperfusion (I/R) injury, a model that closely mimics acute myocardial infarction in humans, is still unknown.