Hypoxia Accelerates Aggressiveness of Hepatocellular Carcinoma Cells Involving Oxidative Stress, Epithelial-Mesenchymal Transition and Non-Canonical Hedgehog Signaling | Zendy

Zhikui Liu | Zendy; Kangsheng Tu | Zendy; Yufeng Wang | Zendy; Bowen Yao | Zendy; Qing Li | Zendy; Liang Wang | Zendy; Changwei Dou | Zendy; Qingguang Liu | Zendy; Xin Zheng | Zendy

Open Access

Hypoxia Accelerates Aggressiveness of Hepatocellular Carcinoma Cells Involving Oxidative Stress, Epithelial-Mesenchymal Transition and Non-Canonical Hedgehog Signaling

Author(s) -

Zhikui Liu,

Kangsheng Tu,

Yufeng Wang,

Bowen Yao,

Qing Li,

Liang Wang,

Changwei Dou,

Qingguang Liu,

Xin Zheng

Publication year - 2017

Publication title -

cellular physiology and biochemistry

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.486

H-Index - 87

eISSN - 1421-9778

pISSN - 1015-8987

DOI - 10.1159/000485821

Subject(s) - gli1 , epithelial–mesenchymal transition , hypoxia (environmental) , cancer research , cyclopamine , nicotinamide adenine dinucleotide phosphate , smoothened , chemistry , hedgehog signaling pathway , hccs , biology , signal transduction , microbiology and biotechnology , downregulation and upregulation , hepatocellular carcinoma , biochemistry , oxidase test , organic chemistry , oxygen , gene , enzyme

Hypoxic microenvironment, a common feature of hepatocellular carcinoma (HCC), can induce HIF-1α expression and promote the epithelial-mesenchymal transition (EMT) and invasion of cancer cells. However, the underlying molecular mechanisms have not fully elucidated.

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