Open AccessHypoxia Accelerates Aggressiveness of Hepatocellular Carcinoma Cells Involving Oxidative Stress, Epithelial-Mesenchymal Transition and Non-Canonical Hedgehog Signaling
Author(s) -
Zhikui Liu,
Kangsheng Tu,
Yufeng Wang,
Bowen Yao,
Qing Li,
Liang Wang,
Changwei Dou,
Qingguang Liu,
Xin Zheng
Publication year - 2017
Publication title -
cellular physiology and biochemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.486
H-Index - 87
eISSN - 1421-9778
pISSN - 1015-8987
DOI - 10.1159/000485821
Subject(s) - gli1 , epithelial–mesenchymal transition , hypoxia (environmental) , cancer research , cyclopamine , nicotinamide adenine dinucleotide phosphate , smoothened , chemistry , hedgehog signaling pathway , hccs , biology , signal transduction , microbiology and biotechnology , downregulation and upregulation , hepatocellular carcinoma , biochemistry , oxidase test , organic chemistry , oxygen , gene , enzyme
Hypoxic microenvironment, a common feature of hepatocellular carcinoma (HCC), can induce HIF-1α expression and promote the epithelial-mesenchymal transition (EMT) and invasion of cancer cells. However, the underlying molecular mechanisms have not fully elucidated.