Open AccessGLP-1 and Ghrelin Attenuate High Glucose/High Lipid-Induced Apoptosis and Senescence of Human Microvascular Endothelial Cells
Author(s) -
Peng-zhi Liao,
Dan Yang,
Duan Liu,
Yuehong Zheng
Publication year - 2017
Publication title -
cellular physiology and biochemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.486
H-Index - 87
eISSN - 1421-9778
pISSN - 1015-8987
DOI - 10.1159/000485820
Subject(s) - ghrelin , protein kinase b , endocrinology , apoptosis , medicine , p38 mitogen activated protein kinases , signal transduction , senescence , biology , microbiology and biotechnology , chemistry , mapk/erk pathway , hormone , biochemistry
GLP-1 and ghrelin are common appetite-regulating hormones. Both have multiple functions beyond metabolic regulation. However, the effects of GLP-1 and ghrelin on endothelial biology are not fully understood. Here, we investigate the roles of GLP-1 and ghrelin in microvascular endothelial apoptosis and senescence.