Open AccessCalycosin Inhibits the Migration and Invasion of Human Breast Cancer Cells by Down-Regulation of Foxp3 Expression
Author(s) -
Shuangxi Li,
Yafei Wang,
Chan Feng,
Wu Guoli,
Yao Yu,
Jing Tian
Publication year - 2017
Publication title -
cellular physiology and biochemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.486
H-Index - 87
eISSN - 1421-9778
pISSN - 1015-8987
DOI - 10.1159/000485784
Subject(s) - calycosin , mcf 7 , viability assay , cancer research , mtt assay , breast cancer , cancer cell , apoptosis , cancer , vascular endothelial growth factor , cell growth , cell migration , cell culture , chemistry , medicine , cell , biology , human breast , vegf receptors , biochemistry , daidzein , genetics , formononetin , genistein
Calycosin, a phytoestrogenic compound, has recently emerged as a promising antitumor drug. It has been shown that calycosin suppresses growth and induces apoptosis of breast cancer cells. However, the effect of calycosin on migration and invasion of breast cancer cells and the underlying molecular mechanisms have not been elucidated.