Open AccessLysine Restriction Affects Feed Intake and Amino Acid Metabolism via Gut Microbiome in Piglets
Author(s) -
Jie Yin,
Hui Han,
Yuying Li,
Zhaojin Liu,
Yurong Zhao,
Fang Rejun,
Xingguo Huang,
Jie Zheng,
Wenkai Ren,
Fei Wu,
Gang Liu,
Xin Wu,
Kai Wang,
Liping Sun,
Chunyong Li,
Tiejun Li,
Yulong Yin
Publication year - 2017
Publication title -
cellular physiology and biochemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.486
H-Index - 87
eISSN - 1421-9778
pISSN - 1015-8987
DOI - 10.1159/000485782
Subject(s) - lysine , biology , biochemistry , microbiome , methionine , amino acid , metabolism , genetics
Our previous reports suggested that dietary supplementation with lysine influenced intestinal absorption and metabolism of amino acids. In this study, we further investigated the effect of lysine restriction (30%) on feed intake and we also tested the hypothesis that gut microbiome contributed to the potential mechanism of lysine restriction-mediated feeding behavior. Here, we profiled gut microbial communities by sequencing 16S ribosomal ribonucleic acid (rRNA) genes from gut samples as well as growth performance, serum hormones, and intestinal lysine transport in a piglet model.