Open AccessMicroRNA-122 Inhibits Lipid Droplet Formation and Hepatic Triglyceride Accumulation via Yin Yang 1
Author(s) -
Guoyi Wu,
Rui Chen,
Ji-Qiao Chen,
Eiketsu Sho,
Shanshan Zhan,
Xianwen Yuan,
Yitao Ding
Publication year - 2017
Publication title -
cellular physiology and biochemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.486
H-Index - 87
eISSN - 1421-9778
pISSN - 1015-8987
DOI - 10.1159/000485765
Subject(s) - farnesoid x receptor , small heterodimer partner , microrna , chemistry , mir 122 , luciferase , microbiology and biotechnology , nonalcoholic fatty liver disease , transfection , biology , fatty liver , biochemistry , medicine , nuclear receptor , transcription factor , gene , disease
An increase in intracellular lipid droplet formation and hepatic triglyceride (TG) content usually results in nonalcoholic fatty liver disease. However, the mechanisms underlying the regulation of hepatic TG homeostasis remain unclear.