Open AccessCelecoxib Down-Regulates the Hypoxia-Induced Expression of HIF-1α and VEGF Through the PI3K/AKT Pathway in Retinal Pigment Epithelial Cells
Author(s) -
Yuxin Sun,
Na Cai,
Ningning Liu
Publication year - 2017
Publication title -
cellular physiology and biochemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.486
H-Index - 87
eISSN - 1421-9778
pISSN - 1015-8987
DOI - 10.1159/000485764
Subject(s) - pi3k/akt/mtor pathway , protein kinase b , celecoxib , ly294002 , angiogenesis , vascular endothelial growth factor , hypoxia (environmental) , chemistry , hypoxia inducible factors , vascular endothelial growth factor a , cancer research , signal transduction , biology , pharmacology , microbiology and biotechnology , vegf receptors , biochemistry , organic chemistry , oxygen , gene
The goal of this study was to detect the expression of hypoxia-inducible factor 1α (HIF-1α) and vascular endothelial growth factor (VEGF) in human retinal pigmented epithelial (RPE) cells treated with celecoxib, a selective cyclooxygenase-2 (COX-2) inhibitor, under hypoxic and normoxic conditions and to explore the signaling mechanism involved in regulating the hypoxia-induced expression of HIF-1α and VEGF in RPE cells.