Celecoxib Down-Regulates the Hypoxia-Induced Expression of HIF-1α and VEGF Through the PI3K/AKT Pathway in Retinal Pigment Epithelial Cells | Zendy

Yizhou Sun | Zendy; Na Cai | Zendy; Ningning Liu | Zendy

Open Access

Celecoxib Down-Regulates the Hypoxia-Induced Expression of HIF-1α and VEGF Through the PI3K/AKT Pathway in Retinal Pigment Epithelial Cells

Author(s) -

Yizhou Sun,

Na Cai,

Ningning Liu

Publication year - 2017

Publication title -

cellular physiology and biochemistry

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.486

H-Index - 87

eISSN - 1421-9778

pISSN - 1015-8987

DOI - 10.1159/000485764

Subject(s) - pi3k/akt/mtor pathway , protein kinase b , celecoxib , ly294002 , angiogenesis , vascular endothelial growth factor , hypoxia (environmental) , chemistry , hypoxia inducible factors , vascular endothelial growth factor a , cancer research , signal transduction , biology , pharmacology , microbiology and biotechnology , vegf receptors , biochemistry , organic chemistry , oxygen , gene

The goal of this study was to detect the expression of hypoxia-inducible factor 1α (HIF-1α) and vascular endothelial growth factor (VEGF) in human retinal pigmented epithelial (RPE) cells treated with celecoxib, a selective cyclooxygenase-2 (COX-2) inhibitor, under hypoxic and normoxic conditions and to explore the signaling mechanism involved in regulating the hypoxia-induced expression of HIF-1α and VEGF in RPE cells.

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