Open AccessTaurine Protects Mouse Spermatocytes from Ionizing Radiation-Induced Damage Through Activation of Nrf2/HO-1 Signaling
Author(s) -
Wenjun Yang,
Jinfeng Huang,
Bao Xiao,
Yan Liu,
Yiqing Zhu,
Fang Wang,
Shuhan Sun
Publication year - 2017
Publication title -
cellular physiology and biochemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.486
H-Index - 87
eISSN - 1421-9778
pISSN - 1015-8987
DOI - 10.1159/000485762
Subject(s) - taurine , ionizing radiation , cytoprotection , apoptosis , viability assay , non ionizing radiation , cell cycle checkpoint , cell cycle , signal transduction , microbiology and biotechnology , biology , chemistry , cancer research , biochemistry , irradiation , physics , amino acid , quantum mechanics , nuclear physics
The increasing prevalence of ionizing radiation exposure has inevitably raised public concern over the potential detrimental effects of ionizing radiation on male reproductive system function. The detection of drug candidates to prevent reproductive system from damage caused by ionizing radiation is urgent. We aimed to investigate the protective role of taurine on the injury of mouse spermatocyte-derived cells (GC-2) subjected to ionizing radiation.