Open AccessProteomic Analysis Reveals a New Benefit of Periodic Mechanical Stress on Chondrocytes
Author(s) -
Li Zeng,
Zhen Wang,
Shun Xu,
Wen-Wei Liang,
Weimin Fan
Publication year - 2017
Publication title -
cellular physiology and biochemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.486
H-Index - 87
eISSN - 1421-9778
pISSN - 1015-8987
DOI - 10.1159/000485652
Subject(s) - phosphorylation , western blot , microbiology and biotechnology , gsk3b , gsk 3 , beta catenin , proteomics , protein phosphorylation , chemistry , biology , wnt signaling pathway , signal transduction , biochemistry , protein kinase a , gene
In recent years, a variety of studies have been performed to investigate the cellular responses of periodic mechanical stress. In our previous studies, we found that periodic mechanical stress can promote proliferation and matrix synthesis through the integrin beta 1-mediated ERK1/2 pathway, and we used proteomic analysis to detect quantitative changes in chondrocytes under periodic mechanical stress. Despite these results, the effects and mechanisms of periodic mechanical stress are still not fully understood, so in this study we extended our study using phosphoproteomic techniques.