Open AccessCirculating Long Noncoding RNA HOTAIR is an Essential Mediator of Acute Myocardial Infarction
Author(s) -
Lu Gao,
Yuan Liu,
Sen Guo,
Rui Yao,
Leiming Wu,
Lili Xiao,
Zheng Wang,
Yuzhou Liu,
Yanzhou Zhang
Publication year - 2017
Publication title -
cellular physiology and biochemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.486
H-Index - 87
eISSN - 1421-9778
pISSN - 1015-8987
DOI - 10.1159/000485588
Subject(s) - hotair , long non coding rna , hox gene , biology , myocardial infarction , cancer research , microrna , non coding rna , medicine , bioinformatics , gene expression , rna , gene , genetics
Acute myocardial infarction (AMI) is one of the leading causes of death in the world. However, specific diagnostic biomarkers have not been fully determined, and candidate regulatory targets for AMI have not been identified to date. Long noncoding RNAs (lncRNAs) are a class of RNA molecules that have diverse regulatory functions during embryonic development, normal life, and disease in higher organisms. However, research on the role of lncRNAs in cardiovascular diseases, particularly AMI, is still in its infancy. HOX antisense intergenic RNA (HOTAIR), a 2.2 kb lncRNA, was initially described as a modulator of HOX gene expression. Recent studies have illustrated the important role of HOTAIR in cancer progression, but few studies have reported its function in cardiac disease, including AMI. In the current study, we aimed to detect the expression of HOTAIR during AMI and to explore its function in hypoxia-induced cardiomyocyte injury in neonatal cardiomyocytes.