Alpha-Mangostin Suppresses the Metastasis of Human Renal Carcinoma Cells by Targeting MEK/ERK Expression and MMP-9 Transcription Activity | Zendy

ChienMin Chen | Zendy; Shu-Ching Hsieh | Zendy; ChiaLiang Lin | Zendy; Yu-Syun Lin | Zendy; JenPi Tsai | Zendy; YiHsien Hsieh | Zendy

Open Access

Alpha-Mangostin Suppresses the Metastasis of Human Renal Carcinoma Cells by Targeting MEK/ERK Expression and MMP-9 Transcription Activity

Author(s) -

ChienMin Chen,

Shu-Ching Hsieh,

ChiaLiang Lin,

Yu-Syun Lin,

JenPi Tsai,

YiHsien Hsieh

Publication year - 2017

Publication title -

cellular physiology and biochemistry

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.486

H-Index - 87

eISSN - 1421-9778

pISSN - 1015-8987

DOI - 10.1159/000485582

Subject(s) - mapk/erk pathway , cancer research , viability assay , cell migration , chemistry , mmp2 , mtt assay , matrix metalloproteinase , cell cycle , mmp9 , cell growth , mek inhibitor , flow cytometry , cell , microbiology and biotechnology , metastasis , biology , downregulation and upregulation , phosphorylation , cancer , biochemistry , gene , genetics

α-mangostin has anti-carcinogenic effects against several cancers. We investigated the molecular mechanism of this compound on the metastasis of human renal carcinoma cells.

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