Open AccessAlpha-Mangostin Suppresses the Metastasis of Human Renal Carcinoma Cells by Targeting MEK/ERK Expression and MMP-9 Transcription Activity
Author(s) -
ChienMin Chen,
Shu-Ching Hsieh,
ChiaLiang Lin,
Yu-Syun Lin,
Jen-Pi Tsai,
YiHsien Hsieh
Publication year - 2017
Publication title -
cellular physiology and biochemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.486
H-Index - 87
eISSN - 1421-9778
pISSN - 1015-8987
DOI - 10.1159/000485582
Subject(s) - mapk/erk pathway , cancer research , viability assay , cell migration , chemistry , mmp2 , mtt assay , matrix metalloproteinase , cell cycle , mmp9 , cell growth , mek inhibitor , flow cytometry , cell , microbiology and biotechnology , metastasis , biology , downregulation and upregulation , phosphorylation , cancer , biochemistry , gene , genetics
α-mangostin has anti-carcinogenic effects against several cancers. We investigated the molecular mechanism of this compound on the metastasis of human renal carcinoma cells.