Open AccessThe Key Roles of GSK-3β in Regulating Mitochondrial Activity
Author(s) -
Kai Yang,
Zhixi Chen,
Juanjuan Gao,
Weimei Shi,
Linfu Li,
Shan Jiang,
Haibo Hu,
Zhiping Liu,
Daohua Xu,
Longhuo Wu
Publication year - 2017
Publication title -
cellular physiology and biochemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.486
H-Index - 87
eISSN - 1421-9778
pISSN - 1015-8987
DOI - 10.1159/000485580
Subject(s) - mitochondrial biogenesis , mitochondrion , microbiology and biotechnology , gsk 3 , biology , mitochondrial permeability transition pore , dnaja3 , pink1 , mitophagy , mitochondrial fusion , kinase , biochemistry , mitochondrial dna , apoptosis , autophagy , programmed cell death , gene
Glycogen synthase kinase-3β (GSK-3β), a serine/threonine protein kinase, has been reported to show essential roles in molecular pathophysiology of many diseases. Mitochondrion is a dynamic organelle for producing cellular energy and determining cell fates. Stress-induced translocated GSK-3β may interact with mitochondrial proteins, including PI3K-Akt, PGC-1α, HK II, PKCε, components of respiratory chain, and subunits of mPTP. Mitochondrial pool of GSK-3β has been implicated in mediation of mitochondrial functions. GSK-3β exhibits the regulatory effects on mitochondrial biogenesis, mitochondrial bioenergetics, mitochondrial permeability, mitochondrial motility, and mitochondrial apoptosis. The versatile functions of GSK-3β might be associated with its wide range of substrates. Accumulative evidence demonstrates that GSK-3β inactivation may be potentially developed as the promising strategy in management of many diseases, such as Alzheimer's disease (AD) and Parkinson's disease (PD). Intensive efforts have been made for exploring GSK-3β inhibitors. Natural products provide us a great source for screening new lead compounds in inactivation of GSK-3β. The key roles of GSK-3β in mediation of mitochondrial functions are discussed in this review.