Open AccessMüller Cell-Derived PEDF Mediates Neuroprotection via STAT3 Activation
Author(s) -
Wolfdietrich Eichler,
Helena Savković-Cvijić,
Susanne Bürger,
Mike Beck,
Manuela Schmidt,
Peter Wiedemann,
Andreas Reichenbach,
Jan Darius Unterlauft
Publication year - 2017
Publication title -
cellular physiology and biochemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.486
H-Index - 87
eISSN - 1421-9778
pISSN - 1015-8987
DOI - 10.1159/000485537
Subject(s) - pedf , viability assay , stat3 , microbiology and biotechnology , transfection , biology , neuroprotection , cell culture , signal transduction , retinal , neuroscience , biochemistry , genetics
Background/ Aims: This study was performed to reveal signaling pathways exploited by pigment epithelium-derived factor (PEDF) derived from retinal (glial) Müller cells to protect retinal ganglion cells (RGCs) from cell death.