Open AccessADAMTS9 is Silenced by Epigenetic Disruption in Colorectal Cancer and Inhibits Cell Growth and Metastasis by Regulating Akt/p53 Signaling
Author(s) -
Ling Chen,
Jun Tang,
Yixiao Feng,
Shuman Li,
Xiang Qin,
Xueling He,
Guosheng Ren,
Weiyan Peng,
Tingxiu Xiang
Publication year - 2017
Publication title -
cellular physiology and biochemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.486
H-Index - 87
eISSN - 1421-9778
pISSN - 1015-8987
DOI - 10.1159/000485534
Subject(s) - cancer research , colorectal cancer , biology , adamts , metastasis , angiogenesis , dna methylation , cell growth , cancer , cell migration , thrombospondin , cell , metalloproteinase , matrix metalloproteinase , gene expression , biochemistry , genetics , gene
ADAMTS (disintegrin-like and metalloproteinase with thrombospondin motifs) proteins are extracellular zinc metalloproteinases that play an important role in extracellular matrix assembly and degradation, connective tissue structuring, angiogenesis, and cell migration. Multiple studies suggest that ADAMTS proteins (e.g. ADAMTS9) can act as tumor suppressors. In gastric, esophageal, and nasopharyngeal carcinomas ADAMTS9 is frequently down-regulated by promoter methylation. Whether ADAMTS9 can function as a tumor suppressor gene (TSG) in colorectal cancer is still unclear.