Open AccessDynamic Profiling of Insulin Secretion and ATP Generation in Isolated Human and Mouse Islets Reveals Differential Glucose Sensitivity
Author(s) -
Attilio Pingitore,
Inmaculada RuzMaldonado,
Bo Liu,
Guo Cai Huang,
Pratik Choudhary,
Shanta J. Persaud
Publication year - 2017
Publication title -
cellular physiology and biochemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.486
H-Index - 87
eISSN - 1421-9778
pISSN - 1015-8987
DOI - 10.1159/000485532
Subject(s) - glut1 , glut3 , glucose transporter , medicine , endocrinology , islet , insulin , glut2 , biology , glucose transporter type 1 , insulin oscillation , secretion , glut4 , glucose homeostasis , insulin resistance
Rodent islets are often used for basic science research but they do not always recapitulate signalling events in human islets. This study evaluated the glucose-dependent responses of human and mouse islets in terms of dynamic insulin secretion, metabolic coupling and the role of glucose transporters.