Dynamic Profiling of Insulin Secretion and ATP Generation in Isolated Human and Mouse Islets Reveals Differential Glucose Sensitivity | Zendy

Attilio Pingitore | Zendy; Inmaculada RuzMaldonado | Zendy; Bo Liu | Zendy; Guo Huang | Zendy; Pratik Choudhary | Zendy; Shanta J. Persaud | Zendy

Open Access

Dynamic Profiling of Insulin Secretion and ATP Generation in Isolated Human and Mouse Islets Reveals Differential Glucose Sensitivity

Author(s) -

Attilio Pingitore,

Inmaculada RuzMaldonado,

Bo Liu,

Guo Huang,

Pratik Choudhary,

Shanta J. Persaud

Publication year - 2017

Publication title -

cellular physiology and biochemistry

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.486

H-Index - 87

eISSN - 1421-9778

pISSN - 1015-8987

DOI - 10.1159/000485532

Subject(s) - glut1 , glut3 , glucose transporter , medicine , endocrinology , islet , insulin , glut2 , biology , glucose transporter type 1 , insulin oscillation , secretion , glut4 , glucose homeostasis , insulin resistance

Rodent islets are often used for basic science research but they do not always recapitulate signalling events in human islets. This study evaluated the glucose-dependent responses of human and mouse islets in terms of dynamic insulin secretion, metabolic coupling and the role of glucose transporters.

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