Open AccessMiR-146a Aggravates LPS-Induced Inflammatory Injury by Targeting CXCR4 in the Articular Chondrocytes
Author(s) -
Taitao Sun,
Xianjun Li,
Hong-Lian Song,
Fei Gao,
Guangyin Zhou,
Xiaoyan Li,
Zhentong Chen,
Lei Chen
Publication year - 2017
Publication title -
cellular physiology and biochemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.486
H-Index - 87
eISSN - 1421-9778
pISSN - 1015-8987
DOI - 10.1159/000485488
Subject(s) - cxcr4 , viability assay , pi3k/akt/mtor pathway , protein kinase b , chondrocyte , wnt signaling pathway , apoptosis , cancer research , signal transduction , medicine , microrna , inflammation , microbiology and biotechnology , immunology , chemistry , biology , chemokine , cartilage , gene , biochemistry , anatomy
Osteoarthritis (OA) as a degenerative disease is a major problem in ageing populations. To better understand the molecular mechanisms in the pathogenesis of OA, this study explored the role of microRNA (miR)-146a in the articular chondrocytes.