Open AccessMolecular Mechanism of MiR-136-5p Targeting NF-κB/A20 in the IL-17-Mediated Inflammatory Response after Spinal Cord Injury
Author(s) -
Jichen He,
Jinmin Zhao,
Xiaoming Peng,
Xiongzhi Shi,
Shaohui Zong,
Gaofeng Zeng
Publication year - 2017
Publication title -
cellular physiology and biochemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.486
H-Index - 87
eISSN - 1421-9778
pISSN - 1015-8987
DOI - 10.1159/000485452
Subject(s) - chemokine , western blot , gene silencing , inflammation , nf κb , in vivo , spinal cord injury , spinal cord , proinflammatory cytokine , astrocyte , immunology , biology , microrna , medicine , microbiology and biotechnology , neuroscience , central nervous system , biochemistry , gene
The pathophysiology of spinal cord injury (SCI) results in serious damage to the human body via an increase in the secondary biological processes imposed by activated astrocytes. Abnormal expression of microRNAs after SCI has become a potential research focus. However, the underlying mechanisms are poorly understood.