Open AccessPuerarin Enhances Ca2+ Reuptake and Ca2+ Content of Sarcoplasmic Reticulum in Murine Embryonic Stem Cell-Derived Cardiomyocytes via Upregulation of SERCA2a
Author(s) -
Lu Wang,
Yurong Cui,
Qinghua Liu,
Yuanlong Song,
Qinghua Hu,
Ming Tang,
Juergen Hescheler,
Jun Xi
Publication year - 2017
Publication title -
cellular physiology and biochemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.486
H-Index - 87
eISSN - 1421-9778
pISSN - 1015-8987
DOI - 10.1159/000485450
Subject(s) - puerarin , phospholamban , downregulation and upregulation , microbiology and biotechnology , endoplasmic reticulum , calcium , chemistry , reuptake , endocrinology , medicine , biology , biochemistry , pathology , receptor , alternative medicine , gene , serotonin , organic chemistry
The embryonic stem cell-derived cardiomyocytes (ES-CMs) serve as potential sources for cardiac regenerative therapy. However, the immature sarcoplasmic reticulum (SR) function of ES-CMs prevents its application. In this report, we examined the effect of puerarin, an isoflavone compound, on SR function of murine ES-CMs.