Puerarin Enhances Ca2+ Reuptake and Ca2+ Content of Sarcoplasmic Reticulum in Murine Embryonic Stem Cell-Derived Cardiomyocytes via Upregulation of SERCA2a | Zendy

Lu Wang | Zendy; Yurong Cui | Zendy; Qinghua Liu | Zendy; Yuanlong Song | Zendy; Qinghua Hu | Zendy; Ming Tang | Zendy; Jürgen Hescheler | Zendy; Jiaoya Xi | Zendy

Open Access

Puerarin Enhances Ca2+ Reuptake and Ca2+ Content of Sarcoplasmic Reticulum in Murine Embryonic Stem Cell-Derived Cardiomyocytes via Upregulation of SERCA2a

Author(s) -

Lu Wang,

Yurong Cui,

Qinghua Liu,

Yuanlong Song,

Qinghua Hu,

Ming Tang,

Jürgen Hescheler,

Jiaoya Xi

Publication year - 2017

Publication title -

cellular physiology and biochemistry

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.486

H-Index - 87

eISSN - 1421-9778

pISSN - 1015-8987

DOI - 10.1159/000485450

Subject(s) - puerarin , phospholamban , downregulation and upregulation , microbiology and biotechnology , endoplasmic reticulum , calcium , chemistry , reuptake , endocrinology , medicine , biology , biochemistry , pathology , receptor , alternative medicine , gene , serotonin , organic chemistry

The embryonic stem cell-derived cardiomyocytes (ES-CMs) serve as potential sources for cardiac regenerative therapy. However, the immature sarcoplasmic reticulum (SR) function of ES-CMs prevents its application. In this report, we examined the effect of puerarin, an isoflavone compound, on SR function of murine ES-CMs.

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