Open AccessLong Non-Coding RNA Linc-USP16 Functions As a Tumour Suppressor in Hepatocellular Carcinoma by Regulating PTEN Expression
Author(s) -
Jidong Sui,
Xuejun Yang,
Wenjing Qi,
Kun Guo,
Zhenming Gao,
Liming Wang,
Da Sun
Publication year - 2017
Publication title -
cellular physiology and biochemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.486
H-Index - 87
eISSN - 1421-9778
pISSN - 1015-8987
DOI - 10.1159/000485449
Subject(s) - pten , competing endogenous rna , gene knockdown , biology , cancer research , long non coding rna , suppressor , hepatocellular carcinoma , psychological repression , cell growth , cell culture , microrna , rna interference , gene expression , signal transduction , rna , pi3k/akt/mtor pathway , cancer , gene , microbiology and biotechnology , genetics
Recent evidence has indicated the crucial regulatory roles of long non-coding RNAs (lncRNAs) in tumour biology. In hepatocellular carcinoma (HCC), aberrant expression of lncRNAs plays an essential role in HCC tumourigenesis. However, the potential roles and regulatory mechanisms of the novel human lncRNA, Linc-USP16, in HCC are unclear.