Open AccessCalycosin Suppresses Epithelial Derived Initiative Key Factors and Maintains Epithelial Barrier in Allergic Inflammation via TLR4 Mediated NF-κB Pathway
Author(s) -
Tao Yu,
Yan Wang,
Xiaoyu Wang,
Can Wang,
Kaifang Bao,
Luo Ji,
Guilin Jiang,
Min Hong
Publication year - 2017
Publication title -
cellular physiology and biochemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.486
H-Index - 87
eISSN - 1421-9778
pISSN - 1015-8987
DOI - 10.1159/000485416
Subject(s) - hacat , occludin , western blot , calycosin , tlr4 , chemistry , inflammation , nf κb , allergic inflammation , thymic stromal lymphopoietin , tight junction , proinflammatory cytokine , microbiology and biotechnology , in vitro , immunology , biology , biochemistry , endocrinology , daidzein , formononetin , genistein , gene
Calycosin is a bioactive component of Astragali Radix, a Chinese herb for treating allergy. We have previously demonstrated that calycosin effectively inhibited allergic inflammation efficiently. The aim of this study was to explore the mechanism of calycosin on epithelial cells in allergic inflammation.