Open AccessCetuximab Enhanced the Cytotoxic Activity of Immune Cells during Treatment of Colorectal Cancer
Author(s) -
Lin Wang,
Yu Wei,
Weijia Fang,
Chong Lu,
Jianing Chen,
Guangying Cui,
Hongyan Diao
Publication year - 2017
Publication title -
cellular physiology and biochemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.486
H-Index - 87
eISSN - 1421-9778
pISSN - 1015-8987
DOI - 10.1159/000485404
Subject(s) - cetuximab , immune system , cytotoxic t cell , cd137 , cd8 , cancer research , colorectal cancer , antibody dependent cell mediated cytotoxicity , monoclonal antibody , immunology , interleukin 12 , nkg2d , medicine , antibody , biology , cancer , in vitro , biochemistry
Cetuximab is a chimeric IgG1 monoclonal antibody which targets the extracellular domain of epidermal growth factor receptor. This antibody is widely used for colorectal cancer (CRC) treatment but its influence on the immune system is incompletely understood.