Open AccessCCL2 is Upregulated by Decreased miR-122 Expression in Iron-Overload-Induced Hepatic Inflammation
Author(s) -
Yuxiao Tang,
Wentao Jia,
Xiaowen Niu,
Lusha Wu,
Hui Shen,
Lina Wang,
Ruirui Qi,
Changquan Ling,
Min Li
Publication year - 2017
Publication title -
cellular physiology and biochemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.486
H-Index - 87
eISSN - 1421-9778
pISSN - 1015-8987
DOI - 10.1159/000485355
Subject(s) - inflammation , downregulation and upregulation , ccl2 , chemokine , chemistry , mir 122 , ccl4 , stat3 , oxidative stress , biology , immunology , microrna , signal transduction , biochemistry , carbon tetrachloride , organic chemistry , gene
Iron overload (IO) is accompanied by hepatic inflammation. The chemokine (C-C motif) ligand 2 (CCL2) mediates inflammation, and its overexpression is associated with IO. However, whether IO results in CCL2 overexpression in the liver and the underlying mechanisms are unclear.