Knockdown of CAVEOLIN-1 Sensitizes Human Basal-Like Triple-Negative Breast Cancer Cells to Radiation | Zendy

Man Zou | Zendy; Yanhui Li | Zendy; Shu Xia | Zendy; Qian Chu | Zendy; Xiaoguang Xiao | Zendy; Hong Qiu | Zendy; Yu Chen | Zendy; Zu’an Zheng | Zendy; Fei Liu | Zendy; Liang Zhuang | Zendy; Shiying Yu | Zendy

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Knockdown of CAVEOLIN-1 Sensitizes Human Basal-Like Triple-Negative Breast Cancer Cells to Radiation

Author(s) -

Man Zou,

Yanhui Li,

Shu Xia,

Qian Chu,

Xiaoguang Xiao,

Hong Qiu,

Yu Chen,

Zu’an Zheng,

Fei Liu,

Liang Zhuang,

Shiying Yu

Publication year - 2017

Publication title -

cellular physiology and biochemistry

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.486

H-Index - 87

eISSN - 1421-9778

pISSN - 1015-8987

DOI - 10.1159/000485291

Subject(s) - gene knockdown , clonogenic assay , cancer research , triple negative breast cancer , radiosensitivity , dna damage , gene silencing , biology , apoptosis , chemistry , microbiology and biotechnology , breast cancer , cancer , medicine , radiation therapy , dna , biochemistry , genetics , gene

Triple-negative breast cancer (TNBC) is a high-risk breast cancer phenotype without specific targeted therapy options and is significantly associated with increased local recurrence in patients treated with radiotherapy. CAVEOLIN-1 (CAV-1)-mediated epidermal growth factor receptor (EGFR) nuclear translocation following irradiation promotes DNA repair and thus induces radiation resistance. In this study, we aimed to determine whether knockdown of CAV-1 enhances the radiosensitivity of basal-like TNBC cell lines and to explore the possible mechanisms.

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