Open AccessKnockdown of CAVEOLIN-1 Sensitizes Human Basal-Like Triple-Negative Breast Cancer Cells to Radiation
Author(s) -
Man Zou,
Yanhui Li,
Shu Xia,
Qian Chu,
Xiaoguang Xiao,
Hong Qian,
Yu Chen,
Ziming Zheng,
Fei Liu,
Zhiyong Liang,
Shiying Yu
Publication year - 2017
Publication title -
cellular physiology and biochemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.486
H-Index - 87
eISSN - 1421-9778
pISSN - 1015-8987
DOI - 10.1159/000485291
Subject(s) - gene knockdown , clonogenic assay , cancer research , triple negative breast cancer , radiosensitivity , dna damage , gene silencing , biology , apoptosis , chemistry , microbiology and biotechnology , breast cancer , cancer , medicine , radiation therapy , dna , biochemistry , genetics , gene
Triple-negative breast cancer (TNBC) is a high-risk breast cancer phenotype without specific targeted therapy options and is significantly associated with increased local recurrence in patients treated with radiotherapy. CAVEOLIN-1 (CAV-1)-mediated epidermal growth factor receptor (EGFR) nuclear translocation following irradiation promotes DNA repair and thus induces radiation resistance. In this study, we aimed to determine whether knockdown of CAV-1 enhances the radiosensitivity of basal-like TNBC cell lines and to explore the possible mechanisms.