Open AccessMiRNAs are Unlikely to be Involved in Retinoid Receptor Gene Regulation in Pancreatic Cancer Cells
Author(s) -
Shuai Yin,
Tim Bleul,
Yifan Zhu,
Orkhan Isayev,
Jens Werner,
Alexandr V. Bazhin
Publication year - 2017
Publication title -
cellular physiology and biochemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.486
H-Index - 87
eISSN - 1421-9778
pISSN - 1015-8987
DOI - 10.1159/000485276
Subject(s) - retinoid , retinoid x receptor , microrna , retinoid x receptor alpha , biology , retinoic acid , retinoid x receptor gamma , cancer research , retinoid x receptor beta , receptor , pancreatic cancer , retinoic acid receptor , microbiology and biotechnology , cell culture , nuclear receptor , gene , cancer , genetics , transcription factor
Retinoid receptors and retinoic acid were reported to be down-regulated in pancreatic duct adenocarcinoma (PDAC) compared to normal pancreas. Yet the mechanism of the down-regulation of retinoid receptors is not well defined. The aim of this study was to find out whether selected dysregulated miRNAs in PDAC are responsible for the decreased level of retinoid receptors.