Palmitic Acid Curcumin Ester Facilitates Protection of Neuroblastoma against Oligomeric Aβ40 Insult | Zendy

Zhangyang Qi | Zendy; Meihao Wu | Zendy; Yun Fu | Zendy; Tengfei Huang | Zendy; Tingting Wang | Zendy; Yanjie Sun | Zendy; Feng Zhi-bo | Zendy; Changzheng Li | Zendy

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Palmitic Acid Curcumin Ester Facilitates Protection of Neuroblastoma against Oligomeric Aβ40 Insult

Author(s) -

Zhangyang Qi,

Meihao Wu,

Yun Fu,

Tengfei Huang,

Tingting Wang,

Yanjie Sun,

Feng Zhi-bo,

Changzheng Li

Publication year - 2017

Publication title -

cellular physiology and biochemistry

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.486

H-Index - 87

eISSN - 1421-9778

pISSN - 1015-8987

DOI - 10.1159/000485117

Subject(s) - curcumin , chemistry , reactive oxygen species , in vivo , biochemistry , lipid peroxidation , pharmacology , cytotoxicity , dichlorofluorescein , in vitro , antioxidant , biology , microbiology and biotechnology

The generation of reactive oxygen species (ROS) caused by amyloid-β (Aβ) is considered to be one of mechanisms underlying the development of Alzheimer's disease. Curcumin can attenuate Aβ-induced neurotoxicity through ROS scavenging, but the protective effect of intracellular curcumin on neurocyte membranes against extracellular Aβ may be compromised. To address this issue, we synthesized a palmitic acid curcumin ester (P-curcumin) which can be cultivated on the cell membrane and investigated the neuroprotective effect of P-curcumin and its interaction with Aβ.

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