Open AccessPalmitic Acid Curcumin Ester Facilitates Protection of Neuroblastoma against Oligomeric Aβ40 Insult
Author(s) -
Zhangyang Qi,
Meihao Wu,
Yun Fu,
Tengfei Huang,
Tingting Wang,
Yanjie Sun,
Zhibo Feng,
Changzheng Li
Publication year - 2017
Publication title -
cellular physiology and biochemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.486
H-Index - 87
eISSN - 1421-9778
pISSN - 1015-8987
DOI - 10.1159/000485117
Subject(s) - curcumin , chemistry , reactive oxygen species , in vivo , biochemistry , lipid peroxidation , pharmacology , cytotoxicity , dichlorofluorescein , in vitro , antioxidant , biology , microbiology and biotechnology
The generation of reactive oxygen species (ROS) caused by amyloid-β (Aβ) is considered to be one of mechanisms underlying the development of Alzheimer's disease. Curcumin can attenuate Aβ-induced neurotoxicity through ROS scavenging, but the protective effect of intracellular curcumin on neurocyte membranes against extracellular Aβ may be compromised. To address this issue, we synthesized a palmitic acid curcumin ester (P-curcumin) which can be cultivated on the cell membrane and investigated the neuroprotective effect of P-curcumin and its interaction with Aβ.