Open AccessCurcumin Delays Retinal Degeneration by Regulating Microglia Activation in the Retina of rd1 Mice
Author(s) -
Yanhe Wang,
Zhiyuan Yin,
Lixiong Gao,
Dan Sun,
Xu-Gang Hu,
Langyue Xue,
Jiaman Dai,
Yuxiao Zeng,
Siyu Chen,
Boju Pan,
Min Chen,
Jing Xie,
Haiwei Xu
Publication year - 2017
Publication title -
cellular physiology and biochemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.486
H-Index - 87
eISSN - 1421-9778
pISSN - 1015-8987
DOI - 10.1159/000485085
Subject(s) - curcumin , retinitis pigmentosa , microglia , retinal degeneration , retina , neuroprotection , retinal , macular degeneration , neuroscience , medicine , biology , pharmacology , inflammation , ophthalmology
Retinitis pigmentosa (RP) is characterized by degeneration of photoreceptors, and there are currently no effective treatments for this disease. However, curcumin has shown neuroprotectant efficacy in a RP rat and swine model, and thus, may have neuroprotective effects in this disease.