Open AccessRoscovitine, a CDK5 Inhibitor, Alleviates Sevoflurane-Induced Cognitive Dysfunction via Regulation Tau/GSK3β and ERK/PPARγ/CREB Signaling
Author(s) -
Jianhui Liu,
Junjun Yang,
Yaolin Xu,
Gang Guo,
Li Cai,
Haitao Wu,
Yanhong Zhao,
Xiaoqing Zhang
Publication year - 2017
Publication title -
cellular physiology and biochemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.486
H-Index - 87
eISSN - 1421-9778
pISSN - 1015-8987
DOI - 10.1159/000485008
Subject(s) - creb , sevoflurane , morris water navigation task , cyclin dependent kinase 5 , mapk/erk pathway , medicine , neuroprotection , gsk 3 , hippocampus , cyclic amp response element binding protein , protein kinase a , endocrinology , pharmacology , kinase , neuroscience , biology , microbiology and biotechnology , mitogen activated protein kinase kinase , transcription factor , biochemistry , gene
Multiple exposures to anesthesia in children may increase the risk of developing cognitive impairment. Sevoflurane is an anesthetic that is commonly used in children during surgery. Cyclin-dependent kinase (CDK) 5 is involved in the regulation of sevoflurane-induced cognitive dysfunction, but the mechanistic details remain unclear. The present study evaluated the mechanism by which CDK5 mediates sevoflurane-induced cognitive dysfunction in mice.