Roscovitine, a CDK5 Inhibitor, Alleviates Sevoflurane-Induced Cognitive Dysfunction via Regulation Tau/GSK3β and ERK/PPARγ/CREB Signaling | Zendy

Jianhui Liu | Zendy; Junjun Yang | Zendy; Yinhua Xu | Zendy; Gang Guo | Zendy; Li Cai | Zendy; Heng Wu | Zendy; Yanhong Zhao | Zendy; Xiaoqing Zhang | Zendy

Open Access

Roscovitine, a CDK5 Inhibitor, Alleviates Sevoflurane-Induced Cognitive Dysfunction via Regulation Tau/GSK3β and ERK/PPARγ/CREB Signaling

Author(s) -

Jianhui Liu,

Junjun Yang,

Yinhua Xu,

Gang Guo,

Li Cai,

Heng Wu,

Yanhong Zhao,

Xiaoqing Zhang

Publication year - 2017

Publication title -

cellular physiology and biochemistry

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.486

H-Index - 87

eISSN - 1421-9778

pISSN - 1015-8987

DOI - 10.1159/000485008

Subject(s) - creb , sevoflurane , morris water navigation task , cyclin dependent kinase 5 , mapk/erk pathway , medicine , neuroprotection , gsk 3 , hippocampus , cyclic amp response element binding protein , protein kinase a , endocrinology , pharmacology , kinase , neuroscience , biology , microbiology and biotechnology , mitogen activated protein kinase kinase , transcription factor , biochemistry , gene

Multiple exposures to anesthesia in children may increase the risk of developing cognitive impairment. Sevoflurane is an anesthetic that is commonly used in children during surgery. Cyclin-dependent kinase (CDK) 5 is involved in the regulation of sevoflurane-induced cognitive dysfunction, but the mechanistic details remain unclear. The present study evaluated the mechanism by which CDK5 mediates sevoflurane-induced cognitive dysfunction in mice.

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