Open AccessAcute Effects of Vitamin C Exposure On Colonic Crypts: Direct Modulation of pH Regulation
Author(s) -
Mohammed M. Aldajani,
Clemens N. Vanicek,
Norah Alhazzaa,
Taras Lysyy,
Raghav Agarwal,
John P. Geibel
Publication year - 2017
Publication title -
cellular physiology and biochemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.486
H-Index - 87
eISSN - 1421-9778
pISSN - 1015-8987
DOI - 10.1159/000484914
Subject(s) - chemistry , modulation (music) , vitamin , vitamin c , microbiology and biotechnology , biophysics , biochemistry , biology , physics , acoustics
Colorectal cancer is still considered a leading cause of death in the United States and worldwide. One potential way to improve survival besides detection is to look to new therapeutic agents that can be taken prophylactically to reduce the risk of tumor formation. For cancer cells to grow and invade, a higher (more alkaline) intracellular pH must occur. We chose to examine a specific nutraceutical agent, which is Vitamin C. The acute effect of Vitamin C exposure on normal colonic crypts has been studied, providing some insight into how Vitamin C achieve its effect.