Open AccessMEG3 Suppresses Human Pancreatic Neuroendocrine Tumor Cells Growth and Metastasis by Down-Regulation of Mir-183
Author(s) -
Yuanyuan Zhang,
Hao-Miao Feng
Publication year - 2017
Publication title -
cellular physiology and biochemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.486
H-Index - 87
eISSN - 1421-9778
pISSN - 1015-8987
DOI - 10.1159/000484906
Subject(s) - meg3 , wnt signaling pathway , cancer research , apoptosis , protein kinase b , viability assay , biology , cell growth , flow cytometry , mapk/erk pathway , transfection , pi3k/akt/mtor pathway , metastasis , cell culture , signal transduction , chemistry , microbiology and biotechnology , downregulation and upregulation , cancer , long non coding rna , biochemistry , genetics , gene
Pancreatic neuroendocrine tumors (pNETs) are rare neoplasms which arise from pancreatic islet cells. Recently, lncRNA MEG3 has been reported as a tumor suppressor in variety cancers. This study aimed to reveal the functional effects of MEG3 on pNETs which has not been uncovered previously.