Open AccessXia-Yu-Xue Decoction Inhibits Intestinal Epithelial Cell Apoptosis in CCl4-Induced Liver Fibrosis
Author(s) -
Wenting Ma,
Tao Le,
Wei Zhang,
Yinshen Zhu,
Dongying Xue,
Jie Zhang,
Cheng Liu
Publication year - 2017
Publication title -
cellular physiology and biochemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.486
H-Index - 87
eISSN - 1421-9778
pISSN - 1015-8987
DOI - 10.1159/000484904
Subject(s) - ccl4 , occludin , apoptosis , tight junction , fibrosis , pathology , tunel assay , inflammation , lamina propria , proinflammatory cytokine , western blot , biology , carbon tetrachloride , immunology , medicine , chemistry , immunohistochemistry , epithelium , microbiology and biotechnology , biochemistry , organic chemistry , gene
Intestine-derived endotoxin is thought to play a role in the development of liver fibrosis. However, the pathological change in the intestine during liver fibrosis is still poorly understood. Here, we investigated the effects of Xia-yu-xue decoction (XYXD) on intestinal inflammation, apoptosis, and tight junction integrity in the carbon tetrachloride (CCl4)-induced liver fibrosis.