Propofol Through Upregulating Caveolin-3 Attenuates Post-Hypoxic Mitochondrial Damage and Cell Death in H9C2 Cardiomyocytes During Hyperglycemia | Zendy

Fan Deng | Zendy; Shuang Wang | Zendy; Liangqing Zhang | Zendy; Xiang Xie | Zendy; Shuyun Cai | Zendy; Haobo Li | Zendy; Guiling Xie | Zendy; Huilai Miao | Zendy; Yang Chang-min | Zendy; Xin Liu | Zendy; Zhengyuan Xia | Zendy

Open Access

Propofol Through Upregulating Caveolin-3 Attenuates Post-Hypoxic Mitochondrial Damage and Cell Death in H9C2 Cardiomyocytes During Hyperglycemia

Author(s) -

Fan Deng,

Shuang Wang,

Liangqing Zhang,

Xiang Xie,

Shuyun Cai,

Haobo Li,

Guiling Xie,

Huilai Miao,

Yang Chang-min,

Xin Liu,

Zhengyuan Xia

Publication year - 2017

Publication title -

cellular physiology and biochemistry

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.486

H-Index - 87

eISSN - 1421-9778

pISSN - 1015-8987

DOI - 10.1159/000484680

Subject(s) - oxidative stress , viability assay , lactate dehydrogenase , apoptosis , creatine kinase , pharmacology , mitochondrion , cardioprotection , propofol , adenosine triphosphate , intracellular , chemistry , medicine , biology , endocrinology , ischemia , biochemistry , enzyme

Hearts from diabetic subjects are susceptible to myocardial ischemia reperfusion (I/R) injury. Propofol has been shown to protect against myocardial I/R injury due to its antioxidant properties while the underlying mechanism remained incompletely understood. Thus, this study aimed to determine whether or not propofol could attenuate myocardial I/R injury by attenuating mitochondrial dysfunction/damage through upregulating Caveolin (Cav)-3 under hyperglycemia.

The content you want is available to Zendy users.

Already have an account? Click here to sign in.

Having issues? You can contact us here

Accelerating Research