Open AccessBlockade of Experimental Multiple Sclerosis by Inhibition of the Acid Sphingomyelinase/Ceramide System
Author(s) -
Katrin Anne Becker,
Ramona Halmer,
Laura Davies,
Brian Henry,
Regan Ziobro-Henry,
Yann Decker,
Yang Liu,
Erich Gulbins,
Klaus Faßbender,
Silke Walter
Publication year - 2017
Publication title -
neurosignals
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.755
H-Index - 67
eISSN - 1424-8638
pISSN - 1424-862X
DOI - 10.1159/000484621
Subject(s) - acid sphingomyelinase , experimental autoimmune encephalomyelitis , multiple sclerosis , myelin oligodendrocyte glycoprotein , immunology , ceramide , myelin , central nervous system , medicine , sphingomyelin , biology , apoptosis , biochemistry , cholesterol
Multiple sclerosis (MS) is a severe and common autoimmune disorder of the central nervous system. Despite the availability of several novel treatment options, the disease is still poorly controlled, since the pathophysiological mechanisms are not fully understood.