Open AccessRemote Ischemia Preconditioning Attenuates Blood-Spinal Cord Barrier Breakdown in Rats Undergoing Spinal Cord Ischemia Reperfusion Injury: Associated with Activation and Upregulation of CB1 and CB2 Receptors
Author(s) -
Na Jing,
Bo Fang,
Zhilin Wang,
Hong Ma
Publication year - 2017
Publication title -
cellular physiology and biochemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.486
H-Index - 87
eISSN - 1421-9778
pISSN - 1015-8987
DOI - 10.1159/000484460
Subject(s) - evans blue , medicine , downregulation and upregulation , anesthesia , ischemia , reperfusion injury , occludin , cannabinoid receptor type 2 , cannabinoid receptor , pharmacology , receptor , antagonist , chemistry , tight junction , biochemistry , gene
Remote ischemic preconditioning (RIPC) has protective effects on spinal cord ischemia reperfusion (I/R) injury, but the potential mechanisms remain unclear. In our study, the effects and underlying mechanisms of RIPC on blood-spinal cord barrier (BSCB) breakdown following I/R injury were investigated.