Open AccessDiosgenin, an Activator of 1,25D3-MARRS Receptor/ERp57, Attenuates the Effects of TNF-α by Causing ADAM10-Dependent Ectodomain Shedding of TNF Receptor 1
Author(s) -
Won Seok Yang,
Soo Young Moon,
Mee Jeong Lee,
Eun Kyoung Lee,
Su-Kil Park
Publication year - 2017
Publication title -
cellular physiology and biochemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.486
H-Index - 87
eISSN - 1421-9778
pISSN - 1015-8987
DOI - 10.1159/000484396
Subject(s) - ectodomain , diosgenin , tumor necrosis factor receptor 1 , extracellular , chemistry , microbiology and biotechnology , receptor , biology , biochemistry , organic chemistry , tumor necrosis factor receptor
We investigated how diosgenin, a steroidal sapogenin, has anti-tumor necrosis factor-α (TNF-α) effects in human aortic endothelial cells (HAECs).