Open AccessActivation of ERK and Mutual Regulation of Stat3 and SP1 Contribute to Inhibition of PDK1 Expression by Atractylenolide-1 in Human Lung Cancer Cells
Author(s) -
Qian Xiao,
Fang Zheng,
Jingjing Wu,
Qing Tang,
Wei Wang,
Swei Sunny Hann
Publication year - 2017
Publication title -
cellular physiology and biochemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.486
H-Index - 87
eISSN - 1421-9778
pISSN - 1015-8987
DOI - 10.1159/000484387
Subject(s) - mapk/erk pathway , stat3 , kinase , sp1 transcription factor , microbiology and biotechnology , phosphorylation , biology , cell cycle , transfection , protein kinase a , cell growth , signal transduction , viability assay , cancer research , cell , cell culture , gene expression , promoter , biochemistry , gene , genetics
Atractylodes macrocephula Koidz is an important ingredient in traditional Chinese herbs. One major bioactive compound, atractylenolide-1 (ATL-1), was reported to have anti-inflammatory and anti-tumor activities. However, the underlying molecular mechanism associated to this has not been well elucidated.