Open AccessN-Cadherin Maintains the Healthy Biology of Nucleus Pulposus Cells under High-Magnitude Compression
Author(s) -
Zhenyu Wang,
Jiali Leng,
Yuguang Zhao,
Dehai Yu,
Feng Xu,
Qingxu Song,
Zhigang Qu,
Xiaoxi Zhuang,
Yi Liu
Publication year - 2017
Publication title -
cellular physiology and biochemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.486
H-Index - 87
eISSN - 1421-9778
pISSN - 1015-8987
DOI - 10.1159/000484385
Subject(s) - cadherin , nucleus , microbiology and biotechnology , biology , neuroscience , cell , genetics
Mechanical load can regulate disc nucleus pulposus (NP) biology in terms of cell viability, matrix homeostasis and cell phenotype. N-cadherin (N-CDH) is a molecular marker of NP cells. This study investigated the role of N-CDH in maintaining NP cell phenotype, NP matrix synthesis and NP cell viability under high-magnitude compression.