Open AccessCurcumin-Loaded Nanoparticles Protect Against Rhabdomyolysis-Induced Acute Kidney Injury
Author(s) -
Xiaoling Chen,
Jun Sun,
Hailun Li,
Hongwu Wang,
Yongtao Lin,
Yu Hu,
Donghui Zheng
Publication year - 2017
Publication title -
cellular physiology and biochemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.486
H-Index - 87
eISSN - 1421-9778
pISSN - 1015-8987
DOI - 10.1159/000484233
Subject(s) - curcumin , in vivo , pharmacology , acute kidney injury , oxidative stress , apoptosis , creatinine , chemistry , creatine kinase , rhabdomyolysis , nanocarriers , medicine , kidney , nephrotoxicity , biochemistry , drug , biology , microbiology and biotechnology
Rhabdomyolysis (RM) is a potentially life-threatening condition that results from the breakdown of muscle and consequent release of toxic compounds into circulation. The most common and severe complication of RM is acute kidney injury (AKI). This study aimed to evaluate the efficacy and mechanisms of action of curcumin-loaded nanoparticles (Cur-NP) for treatment of RM-induced AKI.