Open AccessImpaired Arginine Metabolism Coupled to a Defective Redox Conduit Contributes to Low Plasma Nitric Oxide in Polycystic Ovary Syndrome
Author(s) -
Meera B. Krishna,
Annu Joseph,
Philip Thomas,
Belinda Dsilva,
Sathy M. Pillai,
Malini Laloraya
Publication year - 2017
Publication title -
cellular physiology and biochemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.486
H-Index - 87
eISSN - 1421-9778
pISSN - 1015-8987
DOI - 10.1159/000484107
Subject(s) - polycystic ovary , nitric oxide , arginine , microbiology and biotechnology , metabolism , chemistry , redox , endocrinology , ovary , medicine , biology , biochemistry , amino acid , diabetes mellitus , inorganic chemistry , insulin resistance
Though oxidative stress is associated with Polycystic Ovary Syndrome (PCOS), the status of nitric oxide is still unclear. Nitric Oxide (NO) plays pivotal roles in many physiological functions which are compromised in PCOS. Our recent study reveals lowered T-regulatory cells (Tregs) in PCOS, and Treg generation is known to be regulated by NO levels. However concrete evidences are lacking on mechanisms modulating NO levels under PCOS.