Open AccessIsoflavones Induce BEX2-Dependent Autophagy to Prevent ATR-Induced Neurotoxicity in SH-SY5Y Cells
Author(s) -
Peng Li,
Kun Ma,
Haoyu Wu,
Yanping Wu,
Baixiang Li
Publication year - 2017
Publication title -
cellular physiology and biochemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.486
H-Index - 87
eISSN - 1421-9778
pISSN - 1015-8987
DOI - 10.1159/000484075
Subject(s) - autophagy , neuroprotection , chemistry , programmed cell death , isoflavones , neurotoxicity , apoptosis , genistein , pharmacology , microbiology and biotechnology , wortmannin , biochemistry , pi3k/akt/mtor pathway , biology , endocrinology , toxicity , organic chemistry
Atrazine (ATR) is a broad-spectrum herbicide in wide use around the world. However, ATR is neurotoxic and can cause cell death in dopaminergic neurons, leading to neurodegenerative disorders. Autophagy is the basic cellular catabolic process involving the degradation of proteins and damaged organelles. Studies have shown that certain plant compounds can induce autophagy and prevent neuronal cell death. This prompted us to investigate plant compounds that might reduce the neurotoxic effects of ATR.