Open AccessCalcium-Sensing Receptor Stimulation in Cultured Glomerular Podocytes Induces TRPC6-Dependent Calcium Entry and RhoA Activation
Author(s) -
Lei Zhang,
Tianrong Ji,
Qin Wang,
Kexin Meng,
Rui Zhang,
Yang He,
Chia-Shu Liao,
Linlin Ma,
Jundong Jiao
Publication year - 2017
Publication title -
cellular physiology and biochemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.486
H-Index - 87
eISSN - 1421-9778
pISSN - 1015-8987
DOI - 10.1159/000484064
Subject(s) - rhoa , trpc6 , calcium sensing receptor , stress fiber , extracellular , chemistry , stimulation , microbiology and biotechnology , receptor , calcium in biology , endocrinology , actin cytoskeleton , medicine , calcium , cytoskeleton , transient receptor potential channel , signal transduction , biology , biochemistry , focal adhesion , calcium metabolism , cell
Recent studies provided compelling evidence that stimulation of the calcium sensing receptor (CaSR) exerts direct renoprotective action at the glomerular podocyte level. This protective action may be attributed to the RhoA-dependent stabilization of the actin cytoskeleton. However, the underlying mechanisms remain unclear.