The USP7 Inhibitor P5091 Induces Cell Death in Ovarian Cancers with Different P53 Status | Zendy

Mengying Wang | Zendy; Yayun Zhang | Zendy; Taishu Wang | Zendy; Jinrui Zhang | Zendy; Zhu Zhou | Zendy; Yan Sun | Zendy; Shanshan Wang | Zendy; Yulin Shi | Zendy; Xuelin Luan | Zendy; Yingqiu Zhang | Zendy; Yifei Wang | Zendy; Yang Wang | Zendy; Zou Zhong-wen | Zendy; Lan Kang | Zendy; Han Liu | Zendy

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The USP7 Inhibitor P5091 Induces Cell Death in Ovarian Cancers with Different P53 Status

Author(s) -

Mengying Wang,

Yayun Zhang,

Taishu Wang,

Jinrui Zhang,

Zhu Zhou,

Yan Sun,

Shanshan Wang,

Yulin Shi,

Xuelin Luan,

Yingqiu Zhang,

Yifei Wang,

Yang Wang,

Zou Zhong-wen,

Lan Kang,

Han Liu

Publication year - 2017

Publication title -

cellular physiology and biochemistry

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.486

H-Index - 87

eISSN - 1421-9778

pISSN - 1015-8987

DOI - 10.1159/000484062

Subject(s) - ovarian cancer , autophagy , cancer research , apoptosis , programmed cell death , flow cytometry , biology , cell cycle , cell growth , cancer , cell culture , cancer cell , medicine , immunology , biochemistry , genetics

Ovarian cancer is often diagnosed at later stages with poor prognosis. Recent studies have associated the expression of deubiquitylase USP7 with the survival of ovarian cancers. Being a cysteine protease, USP7 could become a target for pharmacological intervention. Therefore, in this study, we assessed the influence of its inhibitor P5091 on ovarian cancer cells.

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