Open AccessThe USP7 Inhibitor P5091 Induces Cell Death in Ovarian Cancers with Different P53 Status
Author(s) -
Mengying Wang,
Yayun Zhang,
Taishu Wang,
Jinrui Zhang,
Zhu Zhou,
Yan Sun,
Shanshan Wang,
Yulin Shi,
Xuelin Luan,
Yingqiu Zhang,
Yifei Wang,
Yang Wang,
Zou Zhong-wen,
Lan Kang,
Han Liu
Publication year - 2017
Publication title -
cellular physiology and biochemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.486
H-Index - 87
eISSN - 1421-9778
pISSN - 1015-8987
DOI - 10.1159/000484062
Subject(s) - ovarian cancer , autophagy , cancer research , apoptosis , programmed cell death , flow cytometry , biology , cell cycle , cell growth , cancer , cell culture , cancer cell , medicine , immunology , biochemistry , genetics
Ovarian cancer is often diagnosed at later stages with poor prognosis. Recent studies have associated the expression of deubiquitylase USP7 with the survival of ovarian cancers. Being a cysteine protease, USP7 could become a target for pharmacological intervention. Therefore, in this study, we assessed the influence of its inhibitor P5091 on ovarian cancer cells.