Open AccessNogo-B Promotes Angiogenesis in Proliferative Diabetic Retinopathy via VEGF/PI3K/Akt Pathway in an Autocrine Manner
Author(s) -
Yuelu Zhang,
Liang Wang,
Yuechan Zhang,
Mo Wang,
Qi Sun,
Fangzhou Xia,
Ruobing Wang,
Lin Liu
Publication year - 2017
Publication title -
cellular physiology and biochemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.486
H-Index - 87
eISSN - 1421-9778
pISSN - 1015-8987
DOI - 10.1159/000484061
Subject(s) - angiogenesis , autocrine signalling , protein kinase b , pi3k/akt/mtor pathway , cancer research , chemistry , microbiology and biotechnology , signal transduction , biology , biochemistry , receptor
Nogo-B, a conservative protein of endoplasmic reticulum, is a member of the reticulon family of proteins. Proliferative diabetic retinopathy (PDR) is the major concerning problem of diabetic retinopathy. This study explored the role of Nogo-B in the regulation of angiogenesis in PDR patients and primary human retinal endothelial cells (HRMECs).