Open AccessAdenovirus-Mediated Expression of BMP-2 and BFGF in Bone Marrow Mesenchymal Stem Cells Combined with Demineralized Bone Matrix For Repair of Femoral Head Osteonecrosis in Beagle Dogs
Author(s) -
Wuxun Peng,
Lei Wang
Publication year - 2017
Publication title -
cellular physiology and biochemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.486
H-Index - 87
eISSN - 1421-9778
pISSN - 1015-8987
DOI - 10.1159/000484026
Subject(s) - mesenchymal stem cell , demineralized bone matrix , medicine , bone marrow , bone morphogenetic protein 2 , beagle , bone morphogenetic protein , stem cell , femoral head , bone matrix , bone healing , bone morphogenetic protein 7 , surgery , pathology , anatomy , dbm , chemistry , microbiology and biotechnology , in vitro , biology , cartilage , materials science , biochemistry , gene , amplifier , optoelectronics , cmos
This study investigated the effect of using adenovirus-mediated expression of bone morphogenetic protein 2 (Ad-BMP-2) and basic fibroblast growth factor (bFGF) in bone marrow mesenchymal stem cells (BMSCs) in combination with a demineralized bone matrix (DBM) to repair osteonecrosis of the femoral head (ONFH) in Beagle dogs.