Open AccessHydrogen-Rich Saline Attenuates Brain Injury Induced by Cardiopulmonary Bypass and Inhibits Microvascular Endothelial Cell Apoptosis Via the PI3K/Akt/GSK3β Signaling Pathway in Rats
Author(s) -
Keyan Chen,
Nan Wang,
Yugang Diao,
Wanwei Dong,
Ying Sun,
Lidan Liu,
Xiaohong Wu
Publication year - 2017
Publication title -
cellular physiology and biochemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.486
H-Index - 87
eISSN - 1421-9778
pISSN - 1015-8987
DOI - 10.1159/000484024
Subject(s) - pi3k/akt/mtor pathway , apoptosis , protein kinase b , cardiopulmonary bypass , signal transduction , medicine , endothelial stem cell , microbiology and biotechnology , chemistry , cancer research , pharmacology , biology , biochemistry , in vitro
Cardiopulmonary bypass (CPB) is prone to inducing brain injury during open heart surgery. A hydrogen-rich solution (HRS) can prevent oxidation and apoptosis, and inhibit inflammation. This study investigated effects of HRS on brain injury induced by CPB and regulatory mechanisms of the PI3K/Akt/GSK3β signaling pathway.