Hydrogen-Rich Saline Attenuates Brain Injury Induced by Cardiopulmonary Bypass and Inhibits Microvascular Endothelial Cell Apoptosis Via the PI3K/Akt/GSK3β Signaling Pathway in Rats | Zendy

Keyan Chen | Zendy; Nan Wang | Zendy; Yugang Diao | Zendy; Wanwei Dong | Zendy; Yingjie Sun | Zendy; Lidan Liu | Zendy; Xiuying Wu | Zendy

Open Access

Hydrogen-Rich Saline Attenuates Brain Injury Induced by Cardiopulmonary Bypass and Inhibits Microvascular Endothelial Cell Apoptosis Via the PI3K/Akt/GSK3β Signaling Pathway in Rats

Author(s) -

Keyan Chen,

Nan Wang,

Yugang Diao,

Wanwei Dong,

Yingjie Sun,

Lidan Liu,

Xiuying Wu

Publication year - 2017

Publication title -

cellular physiology and biochemistry

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.486

H-Index - 87

eISSN - 1421-9778

pISSN - 1015-8987

DOI - 10.1159/000484024

Subject(s) - pi3k/akt/mtor pathway , apoptosis , protein kinase b , cardiopulmonary bypass , signal transduction , medicine , endothelial stem cell , microbiology and biotechnology , chemistry , cancer research , pharmacology , biology , biochemistry , in vitro

Cardiopulmonary bypass (CPB) is prone to inducing brain injury during open heart surgery. A hydrogen-rich solution (HRS) can prevent oxidation and apoptosis, and inhibit inflammation. This study investigated effects of HRS on brain injury induced by CPB and regulatory mechanisms of the PI3K/Akt/GSK3β signaling pathway.

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