Open AccessAstragaloside IV Induced miR-134 Expression Reduces EMT and Increases Chemotherapeutic Sensitivity by Suppressing CREB1 Signaling in Colorectal Cancer Cell Line SW-480
Author(s) -
Ye Qi,
Li Su,
Dagui Chen,
Wenyi Zheng,
Ye Liu
Publication year - 2017
Publication title -
cellular physiology and biochemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.486
H-Index - 87
eISSN - 1421-9778
pISSN - 1015-8987
DOI - 10.1159/000482025
Subject(s) - colorectal cancer , oxaliplatin , cancer research , epithelial–mesenchymal transition , cell growth , medicine , chemotherapy , cancer , signal transduction , transfection , cell culture , oncology , biology , metastasis , microbiology and biotechnology , genetics
Colorectal cancer (CRC) is one of the leading causes of cancer-related deaths worldwide. Although chemotherapy is the primary means in colorectal cancer treatment, it is burdenerd by adverse drug effects. Drug-resistance is one of the most important challenges for chemotherapy and epithelial-mesenchymal transition (EMT) plays critical role in the development of drug resistance.