Open AccessRecurrent Bleedings in Newborn: A Factor VII Deficiency Case Report
Author(s) -
Kim Cattivelli,
Cristina Distefano,
Lorenza Bonetti,
Sophie Testa,
Simona Maria Siboni,
Alessandro Plebani,
Carlo Poggiani
Publication year - 2018
Publication title -
transfusion medicine and hemotherapy
Language(s) - Uncategorized
Resource type - Journals
SCImago Journal Rank - 0.971
H-Index - 39
eISSN - 1660-3818
pISSN - 1660-3796
DOI - 10.1159/000481993
Subject(s) - medicine , factor vii , fresh frozen plasma , coagulation , recombinant factor viia , pediatrics , prothrombin time , platelet , gastroenterology , coagulopathy , immunology
Background: Major hemorrhages in newborns can be caused by several conditions, and knowledge of the differential diagnosis is essential in order to ensure prompt recognition and appropriate treatment. Case Report: We describe the case of a male newborn experiencing recurrent hemorrhages from the first days of life. Laboratory findings showed normal platelet count, hepatic function, and C-reactive protein. Coagulation tests detected an isolated prothrombin time (PT) prolongation and severe factor VII (FVII) deficiency. Conclusion: Inherited FVII deficiency is a rare autosomal recessive bleeding disorder. Clinical presentation is heterogeneous, and bleeding severity is not directly related to FVII levels. Acute bleeding episodes can be treated with human plasma-derived FVII (pdFVII) or recombinant activated FVII (rFVIIa). In case of severe deficiency, prophylaxis must be evaluated. Awareness of this condition is crucial in order to establish prompt diagnosis and treatment.