Open AccessInhibition of Suicidal Erythrocyte Death by Volasertib
Author(s) -
Abdulla Al Mamun Bhuyan,
Aminul Haque,
Itishri Sahu,
Hang Cao,
Michael Kormann,
Florian Läng
Publication year - 2017
Publication title -
cellular physiology and biochemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.486
H-Index - 87
eISSN - 1421-9778
pISSN - 1015-8987
DOI - 10.1159/000481969
Subject(s) - phosphatidylserine , ionomycin , apoptosis , oxidative stress , annexin , annexin a5 , programmed cell death , microbiology and biotechnology , chemistry , biology , biochemistry , intracellular , phospholipid , membrane
The Polo-like kinase 1 (Plk1) inhibitor volasertib is used in the treatment of malignancy. Volasertib is partially effective by triggering suicidal death or apoptosis of tumor cells. Similar to apoptosis of nucleated cells, erythrocytes may enter suicidal cell death or eryptosis, which is characterized by cell membrane scrambling with phosphatidylserine translocation to the cell surface and by cell shrinkage. Stimulators of eryptosis include energy depletion, hyperosmotic shock, oxidative stress and excessive increase of cytosolic Ca2+ activity ([Ca2+]i). The present study explored, whether volasertib impacts on eryptosis.